For largely political reasons, psychedelic research and therapy has been substantially constrained since 1970. However, the past decade has seen a resurgence in psychedelic research, alongside a decline in associated stigmas, and an increase in interest within the general population, the scientific community, and politics. While over one hundred psychedelic trials have been conducted over the past decade, Australia’s first clinical trial – run by PRISM and St Vincent’s Hospital, and co-sponsored by Mind Medicine Australia – is only just kicking off in 2019. We are seeing the emergence of a different paradigm in mental health treatment, with early yet mounting evidence indicating impressive outcomes. This is an historic moment in mental health research and treatment. It is time for Australia to join this exploration.